BDBM402000 5-[[5-[4-[(1-ethyl-4-piperidyl)methylamino]-2-methoxy-phenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrilehydrochloride::US10010547, Example 108::US10973817, Example 108

SMILES CCN1CCC(CNc2ccc(-c3cc(Nc4cnc(cn4)C#N)n[nH]3)c(OC)c2)CC1

InChI Key InChIKey=LXWRSYRPIUVYCD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402000   

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandPNGBDBM402000(US10010547, Example 108 | 5-[[5-[4-[(1-ethyl-4-pip...)
Affinity DataIC50: 0.0430nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Cascadian Therapeutics

US Patent
LigandPNGBDBM402000(US10010547, Example 108 | 5-[[5-[4-[(1-ethyl-4-pip...)
Affinity DataIC50: 0.0430nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required cofactors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent