BDBM402041 Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-methylacrylamido)phenylamino)pyrimidinyl-4-amino)propyl)-4-trifluoromethylbenzamide::US10011571, Example 22

SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(cc3)C(F)(F)F)n2)ccc1F

InChI Key InChIKey=HKHLIDXILYDLFH-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 402041   

TargetTyrosine-protein kinase JAK3(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402041(US10011571, Example 22 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 21nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402041(US10011571, Example 22 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 279nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Blk(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402041(US10011571, Example 22 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 1.66E+3nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402041(US10011571, Example 22 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 1.00E+4nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402041(US10011571, Example 22 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 1.00E+4nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 3(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402041(US10011571, Example 22 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 1.00E+4nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402041(US10011571, Example 22 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 1.00E+4nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402041(US10011571, Example 22 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 1.00E+4nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402041(US10011571, Example 22 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 1.00E+4nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent