BDBM402042 Preparation of N-(3-(5-chloro-2-(4-fluoro-3-(N-methylacrylamido)phenylamino)pyrimidinyl-4-amino)propyl)-4-fluorobenzamide::US10011571, Example 23

SMILES CN(C(=O)C=C)c1cc(Nc2ncc(Cl)c(NCCCNC(=O)c3ccc(F)cc3)n2)ccc1F

InChI Key InChIKey=DYIBUWLFYBFBBS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 402042   

TargetTyrosine-protein kinase JAK3(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402042(US10011571, Example 23 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 11nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 3(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402042(US10011571, Example 23 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 42nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402042(US10011571, Example 23 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 173nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402042(US10011571, Example 23 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 664nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetTyrosine-protein kinase Blk(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402042(US10011571, Example 23 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 855nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 1(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402042(US10011571, Example 23 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 1.23E+3nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402042(US10011571, Example 23 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 1.92E+3nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Shenzhen Chipscreen Biosciences

US Patent
LigandPNGBDBM402042(US10011571, Example 23 | Preparation of N-(3-(5-ch...)
Affinity DataIC50: 1.00E+4nMAssay Description:Briefly, according to the requirements of different kinase reactions, 0.2 μL test compound (50 μM, dissolved in dimethyl sulfoxide (DMSO)) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent