BDBM402281 (9aS)-7-[2,6-difluoro-4-[2-(2- fluorophenyl)ethynyl]phenyl]- 9a-methyl-2-(3-pyridyl)-4,9- dihydro-3H-pyrazino[1,2- c]pyrimidine-1,6,8-trione::US10011607, 109

SMILES C[C@@]12CC(=O)N(C(=O)N1CCN(C2=O)c1cccnc1)c1c(F)cc(cc1F)C#Cc1ccccc1F

InChI Key InChIKey=CKJQCLUHWBKJLT-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402281   

TargetMetabotropic glutamate receptor 4(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM402281(US10011607, 109 | (9aS)-7-[2,6-difluoro-4-[2-(2- f...)
Affinity DataEC50:  56nMAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent