BDBM402352 N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]-2-piperazin- 1-ylpyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 11::US10329295, Example 4

SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCNCC2)c(n1)C(F)(F)F

InChI Key InChIKey=CYCMVSMODQCQKT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402352   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402352(US10329295, Example 4 | N-[1-methyl-3- (trifluorom...)
Affinity DataIC50: 3nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402352(US10329295, Example 4 | N-[1-methyl-3- (trifluorom...)
Affinity DataIC50: 73nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent