BDBM402449 5-[(3R)-3- hydroxypiperidin-1-yl]-N- [1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide::US10329294, Example 23

SMILES Cn1cc(NC(=O)c2cnn3ccc(nc23)N2CCC[C@@H](O)C2)c(n1)C(F)(F)F

InChI Key InChIKey=PAJUFRUFLHDIOZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402449   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402449(US10329294, Example 23 | 5-[(3R)-3- hydroxypiperid...)
Affinity DataIC50: 0.900nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent