BDBM402502 5-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-bromothiophen-3- yl)pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10329294, Example 76

SMILES N[C@H]1CCCC[C@H]1Nc1ccn2ncc(C(=O)Nc3cscc3Br)c2n1

InChI Key InChIKey=GRYRAJOEDQMSFE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402502   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402502(US10329294, Example 76 | 5-{[(1R,2S)-2- aminocyclo...)
Affinity DataIC50: 0.900nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent