BDBM402516 5-[(3R)-3-aminopiperidin- 1-yl]-N-[3- (difluoromethyl)-1- methyl-1H-pyrazol-4- yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10329294, Example 90

SMILES Cn1cc(NC(=O)c2cnn3ccc(nc23)N2CCC[C@@H](N)C2)c(n1)C(F)F

InChI Key InChIKey=WUSRXUOQWIIGCP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402516   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402516(US10329294, Example 90 | 5-[(3R)-3-aminopiperidin-...)
Affinity DataIC50: 0.5nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402516(US10329294, Example 90 | 5-[(3R)-3-aminopiperidin-...)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of recombinant human His-tagged full length IRAK4 expressed in baculovirus expression system using Ser/Thr07 peptide as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed