BDBM402600 5-[(3R,4S)- or (3S,4R)-3- amino-4-fluoropiperidin- 1-yl]-N-[1-methyl-3- (trifluoromethyl)-1H- pyrazo,l-4-yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide::US10329294, Example 174

SMILES Cn1cc(NC(=O)c2cnn3ccc(nc23)N2CC[C@H](F)[C@H](N)C2)c(n1)C(F)(F)F

InChI Key InChIKey=KGUMLEANDLMCCI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402600   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402600(US10329294, Example 174 | 5-[(3R,4S)- or (3S,4R)-3...)
Affinity DataIC50: 1nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent