BDBM402606 5-[(4R)- or (4S)-(5-amino- 3,3-difluoropiperidin-1- yl)-N-[3-(difluoromethyl)- 1-methyl-1H-pyrazol-4- yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10329294, Example 180

SMILES Cn1cc(NC(=O)c2cnn3ccc(nc23)N2C[C@@H](N)CC(F)(F)C2)c(n1)C(F)F

InChI Key InChIKey=FMCYOILPKLBTED-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402606   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402606(US10329294, Example 180 | 5-[(4R)- or (4S)-(5-amin...)
Affinity DataIC50: 0.5nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent