BDBM402630 5-{[(1S,2R)- or (1R,2S)-2- amino-5,5- difluorocyclohexyl]amino}- N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide::US10329294, Example 204::US10329294, Example 206

SMILES Cn1cc(NC(=O)c2cnn3ccc(N[C@H]4CC(F)(F)CC[C@H]4N)nc23)c(n1)C(F)(F)F

InChI Key InChIKey=HQWSHFAIOYKHOB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402630   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402630(US10329294, Example 204 | US10329294, Example 206 ...)
Affinity DataIC50: 0.5nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402630(US10329294, Example 204 | US10329294, Example 206 ...)
Affinity DataIC50: 78nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent