BDBM402659 N-[3-(difluoromethyl)- 1-methyl-1H-pyrazol- 4-yl]-5-[(3R or S, 4R or S-4-fluoropiperidin-3- yl)amino]pyrazolo[1,5- a]pyrimidine-3- carboxamide::US10329294, Example 234::US10329294, Example 236::US10329294, Example 237::US10329294, Example 241

SMILES Cn1cc(NC(=O)c2cnn3ccc(NC4CNCCC4F)nc23)c(n1)C(F)F

InChI Key InChIKey=JVHBWBXJLSSNCW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 402659   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402659(US10329294, Example 234 | US10329294, Example 241 ...)
Affinity DataIC50: 0.600nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402659(US10329294, Example 234 | US10329294, Example 241 ...)
Affinity DataIC50: 0.600nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402659(US10329294, Example 234 | US10329294, Example 241 ...)
Affinity DataIC50: 3nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402659(US10329294, Example 234 | US10329294, Example 241 ...)
Affinity DataIC50: 5nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent