BDBM402660 N-[3-(difluoromethyl)- 1-methyl-1H-pyrazol- 4-yl]-5-{[(3S)- or (3R)- 5,5-difluoropiperidin-3- yl]amino}pyrazolo[1,5- a]pyrimidine-3- carboxamide::US10329294, Example 235

SMILES Cn1cc(NC(=O)c2cnn3ccc(N[C@H]4CNCC(F)(F)C4)nc23)c(n1)C(F)F

InChI Key InChIKey=LUFQRPXONLJCHT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402660   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402660(US10329294, Example 235 | N-[3-(difluoromethyl)- 1...)
Affinity DataIC50: 0.700nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent