BDBM402668 5-[(R or S)-(4,4- difluoropiperidin-3- yl)amino]-N-[1-methyl- 3-(trifluoromethyl)-1H- pyrazol-4- yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10329294, Example 243::US10329294, Example 245

SMILES Cn1cc(NC(=O)c2cnn3ccc(N[C@H]4CNCCC4(F)F)nc23)c(n1)C(F)(F)F

InChI Key InChIKey=DDXOERQEPQGRNP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402668   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402668(US10329294, Example 243 | 5-[(R or S)-(4,4- difluo...)
Affinity DataIC50: 0.5nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402668(US10329294, Example 243 | 5-[(R or S)-(4,4- difluo...)
Affinity DataIC50: 8nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent