BDBM402677 5-[(3R,5R)-3-amino- 5-fluoropiperidin-1- yl]-N-[3- (difluoromethyl)-1- methyl-1H-pyrazol- 4-yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10329294, Example 253

SMILES Cn1cc(NC(=O)c2cnn3ccc(nc23)N2C[C@H](N)C[C@@H](F)C2)c(n1)C(F)F

InChI Key InChIKey=MFEWZCXFYLTEBT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402677   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402677(US10329294, Example 253 | 5-[(3R,5R)-3-amino- 5-fl...)
Affinity DataIC50: 0.5nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent