BDBM402680 5-{[(3R,5S)-5- fluoropiperidin-3- yl]amino}-N-[1-methyl- 3-(trifluoromethyl)-1H- pyrazol-4- yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide hydrochloride::US10329294, Example 257

SMILES Cn1cc(NC(=O)c2cnn3ccc(N[C@H]4CNC[C@@H](F)C4)nc23)c(n1)C(F)(F)F

InChI Key InChIKey=YDTFWUOUKYEIOK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402680   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402680(US10329294, Example 257 | 5-{[(3R,5S)-5- fluoropip...)
Affinity DataIC50: 0.600nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent