BDBM402717 5-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[3- (trifluoromethyl)-1H- pyrazol-4- yl]pyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10329294, Example 301

SMILES N[C@H]1CCCC[C@H]1Nc1ccn2ncc(C(=O)Nc3c[nH]nc3C(F)(F)F)c2n1

InChI Key InChIKey=BKIVHSWBRKTVIW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402717   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402717(US10329294, Example 301 | 5-{[(1R,2S)-2- aminocycl...)
Affinity DataIC50: 0.800nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent