BDBM402719 N-(3-chloro-1-methyl-1H- pyrazol-4-yl)-2-(1,4- diazepan-1-yl)pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 26

SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCCNCC2)c(Cl)n1

InChI Key InChIKey=JELAHGKGSMIQHY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402719   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 402719BDBM402719(US10329295, Example 26 | N-(3-chloro-1-methyl-1H- ...)
Affinity DataIC50: 61nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent