BDBM402934 US10329302, Example 80::US10793579, Example 80::US11702424, Example 80

SMILES CC[C@H]1CN(C[C@@H]1COc1nccc2cc(C(N)=O)c(OC(C)C)cc12)C(=O)CC#N

InChI Key InChIKey=CVZQAWZOXSOTAZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 402934   

LigandChemical structure of BindingDB Monomer ID 402934BDBM402934(US10329302, Example 80 | US10793579, Example 80 | ...)
Affinity DataIC50: 333nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 402934BDBM402934(US10329302, Example 80 | US10793579, Example 80 | ...)
Affinity DataIC50: 333nMAssay Description:Protocol A: To begin the assay, 19 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 0.21 nM F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 402934BDBM402934(US10329302, Example 80 | US10793579, Example 80 | ...)
Affinity DataIC50: 333nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent