BDBM402968 US10329302, Example 115::US10793579, Example 115::US11702424, Example 115

SMILES CC(C)Oc1cc2c(OC[C@@H]3CCNC3)cccc2cc1C(N)=O

InChI Key InChIKey=BQKZFHARXCADIE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 402968   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 402968BDBM402968(US10329302, Example 115 | US10793579, Example 115 ...)
Affinity DataIC50: 61nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 402968BDBM402968(US10329302, Example 115 | US10793579, Example 115 ...)
Affinity DataIC50: 61nMAssay Description:Protocol A: To begin the assay, 19 μL of reaction mixture containing 20 mM HEPES pH=7.5, 5 mM MgCl2, 0.0025% Brij-35, 600 μM ATP, 0.21 nM F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 402968BDBM402968(US10329302, Example 115 | US10793579, Example 115 ...)
Affinity DataIC50: 61nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent