BDBM404341 2-Chloro-6-{3-[4-(4-methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-benzonitrile::USRE46942, Example 1

SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2cccc(Cl)c2C#N)C1=O

InChI Key InChIKey=OXTYNMCLCNPCJW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404341   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Novartis

US Patent
LigandPNGBDBM404341(2-Chloro-6-{3-[4-(4-methoxy-benzoyl)-piperidin-1-y...)
Affinity DataIC50: 81nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Novartis

US Patent
LigandPNGBDBM404341(2-Chloro-6-{3-[4-(4-methoxy-benzoyl)-piperidin-1-y...)
Affinity DataIC50: 162nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent