BDBM404562 (R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpyrimidin-2-yl)amino)-2, 3-difluorobenzamide::US10343992, Example 214::US10689345, Example 214::US11053198, Example 214::US11066365, Example 214::US11390584, Example 214

SMILES Fc1c(Nc2nccc(n2)C2CC2)ccc(C(=O)N[C@@H]2CCN(C2)C#N)c1F

InChI Key InChIKey=XSXTXDWCAMVUOX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 404562   Sort by

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404562((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404562((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Affinity DataIC50: 100nMAssay Description:USP30 Biochemical Fluorescence Intensity Kinetic Assay.Reactions were performed in duplicate in black 384 well plates (small volume, Greiner 784076) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404562((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404562((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Affinity DataIC50: 100nMAssay Description:USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetUbiquitin carboxyl-terminal hydrolase 30(Human)
Missions Therapeutics

US Patent
LigandPNGBDBM404562((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Affinity DataIC50: 100nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent