BDBM404917 1-(4-(6-(2-(4-(3,3- difluorocyclobutoxy)pyridin-2- yl)acetamido)pyridazin-3-yl)butyl)- N-methyl-1H-1,2,3-triazole-4- carboxamide::US10344025, Example 261::US11370786, Example 261

SMILES CNC(=O)c1cn(CCCCc2ccc(NC(=O)Cc3cc(OC4CC(F)(F)C4)ccn3)nn2)nn1

InChI Key InChIKey=BKEKAQIWWXNESW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 404917   

TargetGlutaminase kidney isoform, mitochondrial(Human)
The University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM404917(1-(4-(6-(2-(4-(3,3- difluorocyclobutoxy)pyridin-2-...)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
The University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM404917(1-(4-(6-(2-(4-(3,3- difluorocyclobutoxy)pyridin-2-...)
Affinity DataIC50: 100nMAssay Description:The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
The University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM404917(1-(4-(6-(2-(4-(3,3- difluorocyclobutoxy)pyridin-2-...)
Affinity DataIC50: 100nMAssay Description:The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent