BDBM406060 1-(1',4-dimethyl-1-phenyl- 1H,1'H-[3,4'-bipyrazol]-5-yl)-3- (6-fluoro-2-methylchroman-4- yl)urea::US10351575, Example 14::US10889589, EX. # 14

SMILES CC1CC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnn(C)c2)c2cc(F)ccc2O1

InChI Key InChIKey=RWNUPDXGZVGUOQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406060   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 406060BDBM406060(1-(1',4-dimethyl-1-phenyl- 1H,1'H-[3,4'-bipyrazol]...)
Affinity DataIC50: 550nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 406060BDBM406060(1-(1',4-dimethyl-1-phenyl- 1H,1'H-[3,4'-bipyrazol]...)
Affinity DataIC50: 550nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent