BDBM407984 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((4- hydroxybicyclo[2.2.2] octan-1-yl)amino)-N-((1- methyl-1H-imidazol-4- yl)methyl)nicotinamide::US10336762, Compound 929

SMILES Cn1cnc(CNC(=O)c2cnc(cc2NC23CCC(O)(CC2)CC3)-c2ccc3cc(cnn23)C#N)c1

InChI Key InChIKey=CFMCDFFEPSPWBK-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407984   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407984(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((4- hy...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407984(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((4- hy...)
Affinity DataEC50:  126nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent