BDBM407999 (S)-6-(3-cyano- pyrrolo[1,2-b]pyridazin- 7-yl)-4-((4-hydroxy- bicyclo[2.2.2]octan- 1-yl)amino)-N-(2-(3- hydroxypyrrolidin- 1-yl)-2-oxoethyl) nicotinamide::US10336762, Compound 944

SMILES OC1CCN(C1)C(=O)CNC(=O)c1cnc(cc1NC12CCC(O)(CC1)CC2)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=QRNFDPGAWSFEPU-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407999   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407999((S)-6-(3-cyano- pyrrolo[1,2-b]pyridazin- 7-yl)-4-(...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407999((S)-6-(3-cyano- pyrrolo[1,2-b]pyridazin- 7-yl)-4-(...)
Affinity DataEC50:  209nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent