BDBM408002 (R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(3- (3,3-difluoroazetidin-1- yl)-2-fluoro-3-oxopropyl)- 4-((4-hydroxybicyclo[2.2.2] octan-1-yl)amino) nicotinamide::US10336762, Compound 947

SMILES OC12CCC(CC1)(CC2)Nc1cc(ncc1C(=O)NC[C@@H](F)C(=O)N1CC(F)(F)C1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=IAEDKPJNDZFBBH-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408002   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM408002((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(3-...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM408002((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(3-...)
Affinity DataEC50:  207nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent