BDBM408007 US10336762, Compound 952::methyl (((1r,3r)-3-((2-(3- cyanopyrrolo[1,2-b] pyridazin-7-yl)-5-((2-(3,3- difluoroazetidin-1-yl)-2- oxoethyl)carbamoyl) pyridin-4-yl)amino)cyclo- butyl)methyl)carbamate

SMILES COC(=O)NC[C@H]1C[C@@H](C1)Nc1cc(ncc1C(=O)NCC(=O)N1CC(F)(F)C1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=DNAZVSPXSZSJBU-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408007   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM408007(methyl (((1r,3r)-3-((2-(3- cyanopyrrolo[1,2-b] pyr...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM408007(methyl (((1r,3r)-3-((2-(3- cyanopyrrolo[1,2-b] pyr...)
Affinity DataEC50:  62nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent