BDBM408012 (S)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-((4- hydroxybicyclo[2.2.2]octan- 1-yl)amino)-N-(2-oxo- piperidin-3-yl)nicotinamide::US10336762, Compound 957

SMILES OC12CCC(CC1)(CC2)Nc1cc(ncc1C(=O)N[C@H]1CCCNC1=O)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=YKRLVYQPXHKVAI-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408012   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM408012((S)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-((4...)
Affinity DataIC50: 1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM408012((S)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-((4...)
Affinity DataEC50:  173nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent