BDBM408082 US10336774, Example 67

SMILES N[C@@H]1CC(F)(F)CC11CCN(CC1)c1cnc(Sc2ccnc(N)c2Cl)c(N)n1

InChI Key InChIKey=LKPOLDXMZUASFD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 408082   

LigandPNGBDBM408082(US10336774, Example 67)
Affinity DataIC50: 10nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent