BDBM408170 (R)-(2-(4-(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethyl)piperazin-1-yl)thiazol-5-yl)(4-methylpiperazin-1-yl)methanone and (S)-(2-(4-(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethyl)piperazin-1-yl)thiazol-5-yl)(4-methylpiperazin-1-yl)methanone::US10336775, Example 74::US10336775, Example 75

SMILES CC(N1CCN(CC1)c1ncc(s1)C(=O)N1CCN(C)CC1)c1ccc2OCCOc2c1

InChI Key InChIKey=DJIIAJMZLCJGHS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408170   

TargetProtein O-GlcNAcase(Human)
Asceneuron

US Patent
LigandChemical structure of BindingDB Monomer ID 408170BDBM408170((R)-(2-(4-(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)...)
Affinity DataIC50: 50nMAssay Description:5 μl of the appropriate concentration of a solution of inhibitor in McIlvaine's Buffer (pH 6.5) in 2% DMSO (for a dose response curve calcul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetProtein O-GlcNAcase(Human)
Asceneuron

US Patent
LigandChemical structure of BindingDB Monomer ID 408170BDBM408170((R)-(2-(4-(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)...)
Affinity DataIC50: 5.50E+3nMAssay Description:5 μl of the appropriate concentration of a solution of inhibitor in McIlvaine's Buffer (pH 6.5) in 2% DMSO (for a dose response curve calcul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent