BDBM408314 N-(1-(4-(difluoromethoxy)-2-fluorophenyl)cyclopropyl)-5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)pyrimidin-2-amine ::US10357493, Example 33

SMILES FC(F)Oc1ccc(c(F)c1)C1(CC1)Nc1ncc(cn1)-c1nnc(o1)C(F)F

InChI Key InChIKey=RZQAEHIHNBRXFG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408314   

TargetHistone deacetylase 6(Human)
Selenity Therapeutics (Bermuda)

US Patent
LigandPNGBDBM408314(N-(1-(4-(difluoromethoxy)-2-fluorophenyl)cycloprop...)
Affinity DataIC50: 29nMAssay Description:All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Selenity Therapeutics (Bermuda)

US Patent
LigandPNGBDBM408314(N-(1-(4-(difluoromethoxy)-2-fluorophenyl)cycloprop...)
Affinity DataIC50: 3.00E+4nMAssay Description:All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent