BDBM408396 US10357493, Example 113

SMILES CN(CC(Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(F)cc1)S(C)(=O)=O

InChI Key InChIKey=TUILFUBJYZJQQX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408396   

TargetHistone deacetylase 6(Human)
Selenity Therapeutics (Bermuda)

US Patent
LigandPNGBDBM408396(US10357493, Example 113)
Affinity DataIC50: 21nMAssay Description:All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Selenity Therapeutics (Bermuda)

US Patent
LigandPNGBDBM408396(US10357493, Example 113)
Affinity DataIC50: 3.00E+4nMAssay Description:All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent