BDBM408614 2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-(2-nitro-4-(trifluoromethyl)phenyl)piperidin-4-yl)ethanol ::US10358451, Compound 9

SMILES OC(CC1c2ccccc2-c2cncn12)C1CCN(CC1)c1ccc(cc1[N+]([O-])=O)C(F)(F)F

InChI Key InChIKey=XFFBVAWQPLWYKP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408614   

TargetTryptophan 2,3-dioxygenase(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408614(US10358451, Compound 9 | 2-(5H-imidazo[5,1-a]isoin...)
Affinity DataIC50: 200nMAssay Description:In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408614(US10358451, Compound 9 | 2-(5H-imidazo[5,1-a]isoin...)
Affinity DataIC50: 500nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent