BDBM408631 (1R,2s,3S,5s,7s)-5-(2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)adamantan-2-ol ::US10358451, Compound 17

SMILES OC1C2CC3CC1CC(C3)(C2)C(=O)CC1c2c(cccc2F)-c2cncn12

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408631   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408631(US10358451, Compound 17 | (1R,2s,3S,5s,7s)-5-(2-(6...)
Affinity DataIC50: 100nMAssay Description:In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM408631(US10358451, Compound 17 | (1R,2s,3S,5s,7s)-5-(2-(6...)
Affinity DataIC50: 200nMAssay Description:In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent