BDBM409017 US10377744, Compound No. 37::US11123311, Compound 37::US11723929, Compound 37
SMILES Fc1cc(NC(=O)NC2CCN(CC2)C(=O)C2CCOCC2)ccc1C(F)(F)F
InChI Key InChIKey=URTSWJJCYYAXTE-UHFFFAOYSA-N
Data 4 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 409017
Affinity DataKi: 3.80nMAssay Description:Inhibition of recombinant human sEH expressed in baculovirus expression system assessed as reduction in ACPU binding incubated for 1 hr by FRET displ...More data for this Ligand-Target Pair
Affinity DataKi: 3.83nMAssay Description:Scores of sEH inhibitors are known, of a variety of chemical structures. Derivatives in which the urea, carbamate or amide pharmacophore are particul...More data for this Ligand-Target Pair
Affinity DataKi: 3.83nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
Affinity DataKi: 3.83nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair