BDBM409980 2-Amino-8-(6-phenyl-3,6-diazabicyclo[3.1.1]heptane-3-carbonyl)-N,N-dipropyl-3H-1-benzazepine-4-carboxamide::US10370338, Example 12

SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2CC(C1)N2c1ccccc1

InChI Key InChIKey=PRCAKRQSXQEPPW-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 409980   

TargetToll-like receptor 8(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM409980(2-Amino-8-(6-phenyl-3,6-diazabicyclo[3.1.1]heptane...)
Affinity DataEC50:  22nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM409980(2-Amino-8-(6-phenyl-3,6-diazabicyclo[3.1.1]heptane...)
Affinity DataEC50:  1.10E+4nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent