BDBM409993 2-Amino-8-(3-butoxyazetidine-1-carbonyl)-N,N-dipropyl-3H-1-benzazepine-4-carboxamide::US10370338, Example 25

SMILES CCCCOC1CN(C1)C(=O)c1ccc2C=C(CC(N)=Nc2c1)C(=O)N(CCC)CCC

InChI Key InChIKey=ZBMWOTFMEWLWEO-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 409993   

TargetToll-like receptor 8(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM409993(2-Amino-8-(3-butoxyazetidine-1-carbonyl)-N,N-dipro...)
Affinity DataEC50:  8nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM409993(2-Amino-8-(3-butoxyazetidine-1-carbonyl)-N,N-dipro...)
Affinity DataEC50:  3.11E+4nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent