BDBM410036 US10370339, Example 2-43::methyl 3-(1-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]-6-methoxy-2-{[4-(tri-fluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl)propanoate

SMILES COC(=O)CCc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1OC

InChI Key InChIKey=NQIJSSRDNIHTJV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 410036   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM410036(methyl 3-(1-[(1R,2S,5R)-2-isopropyl-5-methylcycloh...)
Affinity DataIC50: 190nMAssay Description:Mutant IDH1 R132H Biochemical Assay mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (a-KG) to (2R)-2-hydroxyglutarate (2-HG). NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent