BDBM411253 3-(Azetidine-1-sulfonyl)-N-[4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-methyl-5-trifluoromethyl-benzamide::US10385022, Example 249

SMILES COc1cc(F)ccc1-c1ccncc1N(C)C(=O)c1cc(cc(c1)S(=O)(=O)N1CCC1)C(F)(F)F

InChI Key InChIKey=IFLUERBIJHACSZ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 411253   

TargetG-protein coupled bile acid receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM411253(3-(Azetidine-1-sulfonyl)-N-[4-(4-fluoro-2-methoxy-...)
Affinity DataEC50:  19nMAssay Description:CHO-dhfr(minus) cells expressing human GPBAR1 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
US Patent