BDBM411422 US10385052, Example 3

SMILES FC(F)(F)[C@@H](CC#N)NCC1CCC(CC1)N1C=CC(=O)C2C=Nc3[nH]ccc3C12

InChI Key InChIKey=NAUVMLYABVBBBF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 411422   

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical

US Patent
LigandPNGBDBM411422(US10385052, Example 3)
Affinity DataIC50: 1.70nMAssay Description:The JAK inhibitory activities of compounds of the present invention were measured.The enzymes (JAK1, JAK2, JAK3 and Tyk2) were purchased from Carna B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nissan Chemical

US Patent
LigandPNGBDBM411422(US10385052, Example 3)
Affinity DataIC50: 5.10nMAssay Description:The JAK inhibitory activities of compounds of the present invention were measured.The enzymes (JAK1, JAK2, JAK3 and Tyk2) were purchased from Carna B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Nissan Chemical

US Patent
LigandPNGBDBM411422(US10385052, Example 3)
Affinity DataIC50: 10nMAssay Description:The JAK inhibitory activities of compounds of the present invention were measured.The enzymes (JAK1, JAK2, JAK3 and Tyk2) were purchased from Carna B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nissan Chemical

US Patent
LigandPNGBDBM411422(US10385052, Example 3)
Affinity DataIC50: 18nMAssay Description:The JAK inhibitory activities of compounds of the present invention were measured.The enzymes (JAK1, JAK2, JAK3 and Tyk2) were purchased from Carna B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
US Patent