BDBM412567 (Trans-4-isopropoxycyclohexyl) 9-methyl-8-[(1S,4S)-2-oxa-5-azabicyclo[2.2.2]oct-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl]methanone::US10399972, Example 58

SMILES CC(C)O[C@H]1CCC(CC1)C(=O)N1Cc2cccnc2Nc2cc(C)c(cc12)N1C[C@@H]2CC[C@H]1CO2

InChI Key InChIKey=HDMHVZJYESAQHW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 412567   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM412567(US10399972, Example 58 | (Trans-4-isopropoxycycloh...)
Affinity DataIC50: 18.3nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent