BDBM412675 US10399979, Compound 17b

SMILES COc1cc2c3cnc4[nH]ccc4c3n(CC3CCCCC3)c(=O)c2cc1OC

InChI Key InChIKey=RSFALMGMTQBFJZ-UHFFFAOYSA-N

Data  9 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 412675   

TargetTyrosine-protein kinase JAK3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataIC50: 1.65nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of JAK3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to DNA-tagged recombinant human TRKA (475 to 790 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to DNA-tagged recombinant human SNARK (22 to 333 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataIC50: 3.57nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetBMP-2-inducible protein kinase(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataKd:  7.5nMAssay Description:Binding affinity to DNA-tagged recombinant human BIKE (34 to 329 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataKd:  15nMAssay Description:Binding affinity to DNA-tagged recombinant human FLT3 N841I mutant (592 to 969 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataIC50: 39nMAssay Description:Inhibition of TYK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataIC50: 39.4nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetNUAK family SNF1-like kinase 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataKd:  42nMAssay Description:Binding affinity to DNA-tagged recombinant human ARK5 (25 to 332 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataIC50: 125nMAssay Description:Inhibition of JAK1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataIC50: 125nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412675(US10399979, Compound 17b)
Affinity DataIC50: 7.69E+4nMAssay Description:Inhibition of JAK3 in human SZ4 cells assessed as reduction in IL2-stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL2 stimulation...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed