BDBM412685 US10399979, Compound 17i

SMILES COC(=O)[C@@H](C(C)C)n1c2c3cc[nH]c3ncc2c2cc(OC)c(OC)cc2c1=O

InChI Key

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 412685   

TargetTyrosine-protein kinase JAK1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412685(US10399979, Compound 17i)
Affinity DataIC50:  58.3nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent

TargetTyrosine-protein kinase JAK2(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412685(US10399979, Compound 17i)
Affinity DataIC50:  63nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent

TargetTyrosine-protein kinase JAK3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412685(US10399979, Compound 17i)
Affinity DataIC50:  28.9nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412685(US10399979, Compound 17i)
Affinity DataIC50:  257nMAssay Description:Inhibition of TYK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412685(US10399979, Compound 17i)
Affinity DataIC50:  29nMAssay Description:Inhibition of JAK3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412685(US10399979, Compound 17i)
Affinity DataIC50:  63nMAssay Description:Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM412685(US10399979, Compound 17i)
Affinity DataIC50:  58nMAssay Description:Inhibition of JAK1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM412685(US10399979, Compound 17i)
Affinity DataIC50:  256nMAssay Description:Reagents used in JAK inhibition assay: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent