BDBM412730 (2-Cyclopropyl-6-((1- methyl-4-phenyl-1H- imidazol-2-yl) methoxy)imidazo [1,2-b]pyridazin-3- yl)methanol::Roche-Dataset for PDE10A, Compound 168::US10399985, Example 43

SMILES Cn1cc(nc1COc1ccc2nc(C3CC3)c(CO)n2n1)-c1ccccc1

InChI Key InChIKey=MCPXSXNKYRZMBZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412730   

LigandPNGBDBM412730(US10399985, Example 43 | (2-Cyclopropyl-6-((1- met...)
Affinity DataIC50: 166nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed
LigandPNGBDBM412730(US10399985, Example 43 | (2-Cyclopropyl-6-((1- met...)
Affinity DataIC50: 167nMAssay Description:The following test was carried out in order to determine the activity of the compounds of the present invention. PDE10 activity of the compounds of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent