BDBM412748 N-(2-chloro-5-fluoropyridin-4-yl)-2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::US10399987, Example 13

SMILES Cc1nc(ccc1F)-c1nc(Nc2cc(Cl)ncc2F)c2cc[nH]c2n1

InChI Key InChIKey=BNDKPNNQCVKOLA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412748   

TargetTGF-beta receptor type-1 [4-503,T204D](Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412748(US10399987, Example 13 | N-(2-chloro-5-fluoropyrid...)
Affinity DataIC50: 4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412748(US10399987, Example 13 | N-(2-chloro-5-fluoropyrid...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent