BDBM412836 N-[[4-(4-amino-1-cyclohex-2-en-1-yl-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl]methyl]-2-methoxy-benzamide::US10399989, Example 49::US10611766, Example 49

SMILES COc1ccccc1C(=O)NCc1ccc(cc1)-c1nn(C2CCCC=C2)c2ncnc(N)c12

InChI Key InChIKey=BHIIMLQUQYIITN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 412836   

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandPNGBDBM412836(US10399989, Example 49 | N-[[4-(4-amino-1-cyclohex...)
Affinity DataIC50: 0.400nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandPNGBDBM412836(US10399989, Example 49 | N-[[4-(4-amino-1-cyclohex...)
Affinity DataIC50: 0.400nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandPNGBDBM412836(US10399989, Example 49 | N-[[4-(4-amino-1-cyclohex...)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandPNGBDBM412836(US10399989, Example 49 | N-[[4-(4-amino-1-cyclohex...)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandPNGBDBM412836(US10399989, Example 49 | N-[[4-(4-amino-1-cyclohex...)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandPNGBDBM412836(US10399989, Example 49 | N-[[4-(4-amino-1-cyclohex...)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Loxo Oncology

US Patent
LigandPNGBDBM412836(US10399989, Example 49 | N-[[4-(4-amino-1-cyclohex...)
Affinity DataIC50: 55nMAssay Description:EGFR binding affinity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5 nM Recombinant EGFR, var...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Loxo Oncology

US Patent
LigandPNGBDBM412836(US10399989, Example 49 | N-[[4-(4-amino-1-cyclohex...)
Affinity DataIC50: 55nMAssay Description:EGFR binding affinity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5 nM Recombinant EGFR, var...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent