BDBM412866 US10399989, Example 79::US10611766, Example 79

SMILES COc1ccccc1C(=O)NCc1ccc(-c2nn(C3CCCC3)c3ncnc(N)c23)c(C)c1

InChI Key InChIKey=UYLYEFFJOOWKHR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 412866   

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandPNGBDBM412866(US10399989, Example 79 | US10611766, Example 79)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandPNGBDBM412866(US10399989, Example 79 | US10611766, Example 79)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandPNGBDBM412866(US10399989, Example 79 | US10611766, Example 79)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandPNGBDBM412866(US10399989, Example 79 | US10611766, Example 79)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Loxo Oncology

US Patent
LigandPNGBDBM412866(US10399989, Example 79 | US10611766, Example 79)
Affinity DataIC50: 5.50E+3nMAssay Description:EGFR binding affinity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5 nM Recombinant EGFR, var...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Loxo Oncology

US Patent
LigandPNGBDBM412866(US10399989, Example 79 | US10611766, Example 79)
Affinity DataIC50: 5.50E+3nMAssay Description:EGFR binding affinity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5 nM Recombinant EGFR, var...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent