BDBM414002 US10421760, Compound 13

SMILES C=CC(=O)NC1CCCC(=C1)c1ncnc2[nH]cc(-c3cccs3)c12

InChI Key InChIKey=VAQSCHBMTIJOBO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 414002   

TargetTyrosine-protein kinase JAK3(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM414002(US10421760, Compound 13)
Affinity DataIC50: 0.300nMAssay Description:JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM414002(US10421760, Compound 13)
Affinity DataIC50: 490nMAssay Description:JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM414002(US10421760, Compound 13)
Affinity DataIC50: 3.20E+3nMAssay Description:JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent