BDBM414007 US10421760, Comparative Example 2

SMILES C\C=C\C(=O)NC1CCC=C(C1)c1ncnc2[nH]cc(-c3ccccc3)c12

InChI Key InChIKey=GFBWBTIMWXVESY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 414007   

TargetTyrosine-protein kinase JAK3(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM414007(US10421760, Comparative Example 2)
Affinity DataIC50: 27nMAssay Description:JAK3: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM414007(US10421760, Comparative Example 2)
Affinity DataIC50: 600nMAssay Description:JAK 2: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM414007(US10421760, Comparative Example 2)
Affinity DataIC50: 730nMAssay Description:JAK 1: Among materials for the measurement of this inhibiting activity, a substrate peptide and a kinase protein were acquired as follows. As such a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2020
Entry Details
US Patent